Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?

Chronic noncommunicable diseases and population surveys

The epidemiological method, with increasing importance in the area of general health and, in particular, of Public Health, is a relevant field of study. It subsidizes, among other aspects, the definition of public policies on health. Among its several study designs, cross-sectional (or prevalence) studies are robust tools to describe living conditions and health situations of populations and sp...

Noncommunicable diseases.

From the Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston (D.J.H.); the Public Health Foundation of India, New Delhi (K.S.R.); and the World Heart Federation, Geneva (K.S.R.). Address reprint requests to Dr. Hunter at the Departments of Epidemiology and Nutrition, Harvard School of Public Health, 677 Huntington Ave., Boston, MA 02115, or at [email protected]...

Mitochondrial dysfunction in neurodegenerative diseases.

Neurodegenerative diseases are a large group of disabling disorders of the nervous system, characterized by the relative selective death of neuronal subtypes. In most cases, there is overwhelming evidence of impaired mitochondrial function as a causative factor in these diseases. More recently, evidence has emerged for impaired mitochondrial dynamics (shape, size, fission-fusion, distribution, ...

Is Osteoporosis a Common Comorbidity in Different Chronic Airway Diseases?

GDF-15 Is Elevated in Children with Mitochondrial Diseases and Is Induced by Mitochondrial Dysfunction.

BACKGROUND We previously described increased levels of growth and differentiation factor 15 (GDF-15) in skeletal muscle and serum of patients with mitochondrial diseases. Here we evaluated GDF-15 as a biomarker for mitochondrial diseases affecting children and compared it to fibroblast-growth factor 21 (FGF-21). To investigate the mechanism of GDF-15 induction in these pathologies we measured i...